The difference between controlled release and sustained release is that controlled release is a perfectly zero order release; that is, the drug releases over time irrespective of concentration. Sustained release implies slow release of the drug over a time period. It may or may not be controlled release.
There are certain considerations for the formation of sustained release formulation:
If the pharmacological activity of the active compound is not related to its blood levels, time releasing has no purpose then.
If the absorption of the active compound involves an active transport, the development of a time-release product may be problematic.
Finally, if the active compound has a short half-life, it would require a large amount to maintain both prolonged and effective dose. In this case, a broad therapeutic window is necessary to avoid toxicity; otherwise, the risk is unwarranted and another mode of administration would be recommended.
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